Recent Results on Finite and Infinite SysteIlls of Interacting Diffusions

We review some recent results concerning the long time behavior of finite and infinite systems of interacting diffusions. After presenting the basic ergodic theory of the infinite systems, we observe that the long time behavior of the finite systems differs drastically from that of the infinite system, at least from a naive point of view. A theorem comparing the finit.e and infinite systems on different time scales is presented which gives a more complete picture of what is going on.nul

The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis

Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the primary site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.

An intravaginal ring for real-time evaluation of adherence to therapy

© 2017 Moss et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Two recent Phase III clinical trials to investigate an intravaginal ring for preventing HIV infection demonstrated that adherence to prescribed device use was a primary driver of efficacy. Surrogate methods for determining adherence in the studies were limited in their inability to monitor temporal patterns of use and allow deconvolution of the effects of adherence and device efficacy on HIV infection rates. To address this issue, we have developed functionality in an intravaginal ring to continuously monitor when the device is being used and maintain a log of adherence that can be accessed by clinicians after it is removed. An electronic module fabricated with common, inexpensive electronic components was encapsulated in a silicone intravaginal ring. The device uses temperature as a surrogate measure of periods of device insertion and removal, and stores a record of the data for subsequent retrieval. The adherence-monitoring intravaginal ring accurately recorded the device status over 33 simulated IN-OUT cycles and more than 1000 measurement cycles in vitro. Following initial in vitro testing in a temperature-controlled chamber, the device was evaluated in vivo in sheep using a predetermined insertion/removal pattern to simulate intravaginal ring use. After insertion into the vaginal cavity of a sheep, the logged data correctly indicated the device status over 29 hours of continuous measurement including three cycles of insertion and removal. The device described here is a promising, low-cost method for real-time adherence assessment in clinical trials involving medicated intravaginal rings or other intravaginal devices

Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism

The cancer secretome includes all of the macromolecules secreted by cells into their microenvironment. Cancer cell secretomes are significantly different to that of normal cells reflecting the changes that normal cells have undergone during their transition to malignancy. More importantly, cancer secretomes are known to be active mediators of both local and distant host cells and play an important role in the progression and dissemination of cancer. Here we have quantitatively profiled both the composition of breast cancer secretomes associated with osteotropism, and their modulation under normoxic and hypoxic conditions. We detect and quantify 162 secretome proteins across all conditions which show differential hypoxic induction and association with osteotropism. Mass Spectrometry proteomics data have been deposited to the ProteomeXchange Consortium with the dataset identifier PXD000397 and the complete proteomic, bioinformatic and biological analyses are reported in Cox et al. (2015) [1]

Geodesics of Random Riemannian Metrics

We analyze the disordered Riemannian geometry resulting from random perturbations of the Euclidean metric. We focus on geodesics, the paths traced out by a particle traveling in this quenched random environment. By taking the point of the view of the particle, we show that the law of its observed environment is absolutely continuous with respect to the law of the random metric, and we provide an explicit form for its Radon-Nikodym derivative. We use this result to prove a "local Markov property" along an unbounded geodesic, demonstrating that it eventually encounters any type of geometric phenomenon. We also develop in this paper some general results on conditional Gaussian measures. Our Main Theorem states that a geodesic chosen with random initial conditions (chosen independently of the metric) is almost surely not minimizing. To demonstrate this, we show that a minimizing geodesic is guaranteed to eventually pass over a certain "bump surface," which locally has constant positive curvature. By using Jacobi fields, we show that this is sufficient to destabilize the minimizing property.Comment: 55 pages. Supplementary material at arXiv:1206.494

Density classification on infinite lattices and trees

Consider an infinite graph with nodes initially labeled by independent Bernoulli random variables of parameter p. We address the density classification problem, that is, we want to design a (probabilistic or deterministic) cellular automaton or a finite-range interacting particle system that evolves on this graph and decides whether p is smaller or larger than 1/2. Precisely, the trajectories should converge to the uniform configuration with only 0's if p1/2. We present solutions to that problem on the d-dimensional lattice, for any d>1, and on the regular infinite trees. For Z, we propose some candidates that we back up with numerical simulations

Threadleaf Groundsel and Forage Response to Herbicides in the Davis Mountains.

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FACETEQ interface demo for emotion expression in VR

© 2017 IEEE.Faceteq prototype v.05 is a wearable technology for measuring facial expressions and biometric responses for experimental studies in Virtual Reality. Developed by Emteq Ltd laboratory, Faceteq can enable new avenues for virtual reality research through combination of high performance patented dry sensor technologies, proprietary algorithms and real-time data acquisition and streaming. Emteq founded the Faceteq project with the aim to provide a human-centered additional tool for emotion expression, affective human-computer interaction and social virtual environments. The proposed demonstration will exhibit the hardware and its functionality by allowing attendees to experience three of the showcasing applications we developed this year

FACETEQ; A novel platform for measuring emotion in VR

FaceTeq prototype v.05 is a wearable technology for measuring facial expressions and biometric responses for experimental studies in Virtual Reality. Developed by Emteq Ltd laboratory, FaceTeq can enable new avenues for virtual reality research through combination of high performance patented dry sensor technologies, proprietary algorithms and real-time data acquisition and streaming. FaceTeq project was founded with the aim to provide a human-centred additional tool for emotion expression, affective human-computer interaction and social virtual environments. The proposed poster will exhibit the hardware and its functionality

Self-similar stable processes arising from high-density limits of occupation times of particle systems

We extend results on time-rescaled occupation time fluctuation limits of the $(d,\alpha, \beta)$-branching particle system $(0<\alpha \leq 2, 0<\beta \leq 1)$ with Poisson initial condition. The earlier results in the homogeneous case (i.e., with Lebesgue initial intensity measure) were obtained for dimensions $d>\alpha / \beta$ only, since the particle system becomes locally extinct if $d\le \alpha / \beta$. In this paper we show that by introducing high density of the initial Poisson configuration, limits are obtained for all dimensions, and they coincide with the previous ones if $d>\alpha/\beta$. We also give high-density limits for the systems with finite intensity measures (without high density no limits exist in this case due to extinction); the results are different and harder to obtain due to the non-invariance of the measure for the particle motion. In both cases, i.e., Lebesgue and finite intensity measures, for low dimensions ($d<\alpha(1+\beta)/\beta$ and $d<\alpha(2+\beta)/(1+\beta)$, respectively) the limits are determined by non-L\'evy self-similar stable processes. For the corresponding high dimensions the limits are qualitatively different: ${\cal S}'(R^d)$-valued L\'evy processes in the Lebesgue case, stable processes constant in time on $(0,\infty)$ in the finite measure case. For high dimensions, the laws of all limit processes are expressed in terms of Riesz potentials. If $\beta=1$, the limits are Gaussian. Limits are also given for particle systems without branching, which yields in particular weighted fractional Brownian motions in low dimensions. The results are obtained in the setup of weak convergence of S'(R^d)$-valued processes.Comment: 28 page